Scientists map brain network linked to addiction

Researchers said yesterday they had mapped the network in the brain linked to addiction by studying long-time smokers who abruptly quit after suffering brain lesions.

They hope the research will give future treatments a target to aim for in the fight against addiction to a range of substances.

To find out where addiction resides in the brain, the researchers studied 129 patients who were daily smokers when they had a brain lesion.

While more than half kept on smoking as normal after getting the lesion, a quarter immediately quit without any problem -- even reporting an "absence of craving", according to a new study in the journal Nature Medicine.

While the lesions of those who stopped smoking were not located in one specific region of the brain, they mapped them to a number of areas -- what they called the "addiction remission network".

They found that a lesion that would cause someone to give up an addiction would probably affect parts of the brain like the dorsal cingulate, lateral prefrontal cortex and insula -- but not the medial prefrontal cortex.

To confirm their findings, the researchers studied 186 lesion patients who completed an alcohol risk assessment.

They found that lesions in the patients' addiction remission network also reduced the risk of alcoholism, "suggesting a shared network for addiction across these substances of abuse", the study said.