Cristiano Ronaldo, Joao Moutinho and Raphael Guerreiro will all miss Portugal's Nations League match against Switzerland this weekend, coach Fernando Santos announced on Saturday.

An early goal from Pablo Sarabia earned Spain a 1-0 win in Switzerland on Thursday, their first victory of this year's UEFA Nations League.

Portugal scored twice in five minutes to beat the Czech Republic on Thursday and open up a two-point lead at the top of Group A2 in the Nations League.

Gavi became Spain's youngest scorer ever and Inigo Martinez headed home a late equaliser as Spain drew 2-2 with the Czech Republic in the Nations League in Prague on Sunday.

Cristiano Ronaldo scored twice as Portugal swept to an emphatic 4-0 victory over Switzerland in their UEFA Nations League clash at the Estadio Jose Alvalade in Lisbon on Sunday.

Still something of a novelty, UEFA's inaugural Nations League tournament reaches its final stage with a four-team mini-competition in Portugal this week, which will be short and sharp and looks to be a wide-open contest.