Lionel Messi is set to return to action with his club Inter Miami on Saturday after spending over two months out with an ankle injury, Miami coach Gerardo Martino said on Friday.

Luis Suarez struck twice as ten-man Inter Miami became the first team to book their place in this season's Major League Soccer playoffs after beating Cincinnati 2-0 at Chase Stadium on Saturday.

Lionel Messi will miss Inter Miami's next two Major League Soccer matches after injuring his right ankle in Argentina's Copa America final triumph, Miami coach Gerardo Martino said Tuesday.

The league's top talents will face the Mexican League All-Stars on July 24 at Columbus, Ohio.

Inter Miami rested Lionel Messi and Luis Suarez but still managed to extend their unbeaten run in Major League Soccer to 10 games with a hard fought 2-1 win at the Vancouver Whitecaps on Saturday.

Messi, 36, has become the face of MLS since joining Miami last July, but he has yet to make an appearance in Vancouver.

Lionel Messi's record $20.45 million annual salary from Inter Miami makes him by far the best paid player in Major League Soccer but also puts him ahead of the entire squads of 25 of the league's clubs, according to data released by the MLS Players Association on Thursday.

Inter Miami's five-match winning run came to an end on Wednesday as, without the injured Lionel Messi, they were held to a 0-0 draw at Orlando City.

Olivier Giroud confirmed on Monday that he will leave AC Milan at the end of the season to end his long career in Major League Soccer.

Messi's five assists, which all came in the second half, are a new record for an MLS game and he now has 10 goals and 12 assists in eight league appearances so far this season.

A crowd over 65,612 turned up at Gillette Stadium in Foxborough, Massachusetts, the stadium the Revolution share with the NFL's New England Patriots, to see the Argentine World Cup winner.

France's record goal scorer Olivier Giroud has reached agreement with Los Angeles FC to join the Major League Soccer club this summer, sources close to the player confirmed on Tuesday.

Everything Miami was creating was coming through Messi, who flashed a snapshot wide before moments later whipping in a cross for a Gomez header which was saved by Panicco's feet.

Inter Miami, without Lionel Messi, lost 2-1 at home to Mexico's Monterrey in the first leg of their CONCACAF Champions Cup quarter-final on Wednesday with Argentine Jorge Rodriguez scoring a superb 89th-minute winner.

Luis Suarez bagged his fifth goal of the season as Inter Miami were held to a 1-1 draw against New York City FC in Major League Soccer on Saturday.

The New England Revolution are on track to break a 22-year-old attendance record when Lionel Messi and Inter Miami visit on April 27.

Suarez continued his prolific start to life in MLS with his sixth goal in seven games in all competitions for the South Florida club.

Lionel Messi and Inter Miami are ready to push for an MLS Cup title after their pummeling of Orlando City Saturday.

The addition of Suarez gives Messi a third former Barca teammate on Miami's squad and a much-needed secondary goal-scoring option.

The World Cup winner joined Inter from Paris Saint Germain in mid-July, the biggest name ever to move to MLS and his signing caused a massive spurt in interest in American soccer.