For the second successive season, Serie A has one club remaining in the last 16 of the Champions League as Italian football struggles to compete in Europe's premier club competition and risks falling even further behind.

Juventus were left wondering what might have been after coming close to mounting an incredible comeback against Galatasaray with 10 men before eventually being knocked out of the Champions League, 7-5 on aggregate.

Galatasaray scraped through to the last 16 of the Champions League despite throwing away a three-goal aggregate lead at 10-man Juventus on Wednesday, with two extra-time goals limiting the Turkish outfit to a 3-2 defeat.

Juventus were jeered off after capping a dreadful week with a 2-0 home loss to fellow Champions League chasers Como in Serie A on Saturday.

Dutch midfielder Noa Lang scored a brace as Galatasaray thumped Juventus 5-2 in a pulsating contest in Istanbul on Tuesday in the first leg of a Champions League playoff.

Serie A referee designator Gianluca Rocchi said referee Federico La Penna was "clearly wrong" in showing Juventus defender Pierre Kalulu a second yellow card during Saturday's loss at Inter Milan, and apologised over the incident.

Inter hold top spot after a four-match winning run and on Sunday they host Bologna who put an end to their Italian Super Cup hopes this month with a semi-final win on penalties.

Luciano Spalletti has called for calm at Juventus as he insisted their recent performances have been blown out of proportion.

Juventus were held to a 1-1 draw by Sporting Lisbon on Tuesday as Luciano Spalletti's new team failed to claim a first win in this season's Champions League.

Luciano Spalletti got off to a winning start in charge of Juventus on Saturday as his new team beat Cremonese and their goalscorer Jamie Vardy 2-1.

Luciano Spalletti believes Juventus can still mount a Serie A title challenge despite sitting seventh in the standings, as the former Italy boss explained on Friday why he accepted a short-term deal to rescue the struggling side.

Juventus have appointed former Italy manager Luciano Spalletti as head coach until the end of the season, the Serie A club said on Thursday, following the sacking of Igor Tudor.

 Juventus have chosen Luciano Spalletti as their new head coach, Italian newspapers reported on Wednesday, adding that the official announcement is expected late in the day or on Thursday.

Juventus have sacked head coach Igor Tudor after failing to win their last eight matches in all competitions, the Serie A club said on Monday.

"Juventus FC announces that it has today relieved Igor Tudor of his duties as coach of the men's first team, along with his staff," the Italian club said in a statement.

Paulo Dybala scored his first Serie A goal of the season to give Roma a 1-0 victory at Sassuolo on Sunday to lift them level on points with leaders Napoli.

Jude Bellingham's goal helped record 15-time winners Real Madrid maintain their 100 percent start to the Champions League with a 1-0 victory over Juventus on Wednesday.

Dusan Vlahovic and Lloyd Kelly scored in stoppage time to inspire a dramatic Juventus escape, as they secured a 4-4 draw at home to Borussia Dortmund in a Champions League opener on Tuesday where all eight goals came after the break.

"What can I say, it's a dream to play and score such a hugely important goal for Juve," said Adzic.

Nottingham Forest have signed Brazilian midfielder Douglas Luiz from Juventus on an initial season-long loan with a conditional obligation to make it a permanent deal next summer, the Premier League club said.