Alexander Zverev brought the curtain down on a dramatic Friday at the French Open with a late-night 6-4, 6-3, 5-7 6-2 victory over local hope Quentin Halys, to reach a suddenly star-shorn last 16.

With Jannik Sinner's shock French Open exit blowing the men's draw wide open, Novak Djokovic will look to pounce on the opportunity in his pursuit of a record 25th Grand Slam title.

Jannik Sinner's stunning Roland Garros exit shattered what had shaped up as one of the most predictable French Opens since Rafa Nadal's era, throwing the men's draw wide open on Thursday to leave it as finely balanced as the women's field.

Jannik Sinner said his lack of energy in a stunning French Open loss on Thursday was down to a combination of factors including a long claycourt swing, during which he played and won three successive events to arrive as the favourite in Paris.

“I’m happy to be back here, where I have great memories. Overall the first round matches are never easy,” Sinner said before addressing the crowd directly.

Novak Djokovic on Friday admitted world number one Jannik Sinner was the man to beat at Roland Garros as the imperious Italian stands on the brink of completing his career Grand Slam.

Jannik Sinner and Novak Djokovic will not be able to meet until the French Open final after the pair were placed in opposite halves of the men's draw on Thursday, while Coco Gauff could face Aryna Sabalenka in the women's semis.

Jannik Sinner won the Italian Open on Sunday after beating Casper Ruud 6-4, 6-4 to claim a record-extending sixth consecutive Masters 1000 tournament victory.

Jannik Sinner reached the semifinals of the Italian Open on Thursday after seeing off Andrey Rublev and establishing a new record of consecutive wins in Masters 1000 tournaments.

The 24-year-old Italian became the first man to win five successive Masters 1000 crowns on Sunday after dismantling Alexander Zverev 6-1 6-2 in 57 minutes, adding Madrid to recent triumphs in Paris, Indian Wells, Miami and Monte Carlo.

World number one Jannik Sinner dispatched Alexander Zverev 6-1, 6-2 on Sunday to win the Madrid Open for the first time.

Jannik Sinner said the surge of adrenaline that comes with big matches had helped him push through mounting fatigue after the Italian reached his maiden Madrid final following another deep run in a packed season.

World number one Jannik Sinner powered into the Madrid Open final with a 6-2, 6-4 victory over Arthur Fils on Friday, keeping alive his bid for a record fifth successive ATP Masters 1000 title.

World number one Jannik Sinner said Tuesday his principal aim as he prepares for the Madrid Open is to be in the "best possible shape" for Roland Garros next month as he seeks to complete a career Grand Slam.

Spanish tennis star Carlos Alcaraz said Monday his battle with new world number one Jannik Sinner was giving him extra inspiration ahead of the Barcelona Open.

Sinner is expected to return to action in Madrid later this month or in Rome at the beginning of May.

Jannik Sinner beat Carlos Alcaraz in straight sets to win the Monte Carlo Masters for the first time Sunday and reclaim the world number one ranking from his Spanish rival.

Carlos Alcaraz teed up a blockbuster Monte Carlo Masters final with Jannik Sinner as the world's top two players will face off on Sunday for the number one ranking.

Jannik Sinner brushed aside Felix Auger-Aliassime in straight sets on Friday to set up a Monte Carlo Masters semi-final against Alexander Zverev.

World number two Jannik Sinner powered past Jiri Lehecka 6-4, 6-4 to win the ATP Miami Masters 1000 for a second time on Sunday, adding the title to his Indian Wells crown.